GRAFTON — Thousands of cyclists will take to the roads across Massachusetts this weekend as the Pan-Mass Challenge returns on Saturday and Sunday, raising millions of dollars for cancer research and patient care at Dana-Farber Cancer Institute.
As riders make their way from Greater Boston toward Cape Cod, several local communities will once again play host to the annual fundraiser, giving residents an opportunity to line the streets and cheer participants on.
After starting in Worcester, communities including Grafton, Upton, Mendon, and Bellingham will see Pan-Mass Challenge riders pass through as they continue their journey toward the finish line in Provincetown.
Spectators are encouraged to gather along the route with signs, cowbells, flags and plenty of enthusiasm to encourage the cyclists, many of whom are riding in honor or memory of loved ones affected by cancer.
The Pan-Mass Challenge has become one of the nation’s most successful athletic fundraising events, with thousands of riders, volunteers and supporters coming together each year to help advance cancer research. Since its founding in 1980, the event has raised more than $1 billion for Dana-Farber Cancer Institute, with 100 percent of every rider-raised dollar supporting cancer research and patient care.
While the cyclists will spend hours on the road, organizers say the encouragement they receive from communities along the route provides an important boost during the challenging ride.
Residents planning to watch are encouraged to arrive early, as temporary traffic delays and road closures may occur while riders travel through the area. Motorists should use caution, expect increased bicycle traffic throughout the day, and follow directions from public safety officials and event volunteers.
Whether ringing a cowbell, waving a homemade sign or simply applauding as the riders pass by, local communities have an opportunity to play a small but meaningful role in one of Massachusetts’ most impactful annual charitable events.
The Pan-Mass Challenge begins Saturday morning, with riders making their way through Grafton, Upton, Mendon and Bellingham before continuing their journey toward Cape Cod, where the weekend-long ride concludes on Sunday.

